A new global study reveals that in the UK, Manchester is much more conducive to starting up than London. However, if you could start a business anywhere in the world, you might want to head to Vancouver, according to a new study by UK’s leading freelance marketplace PeoplePerHour.

The metrics used to measure the viability of these world capitals as start-up hubs include quality of life, cost of living, rent, cost of starting a business, cost of office space, monthly salary and its ranking within the World Bank’s Doing Business country rankings. It doesn’t take access to finance or the venture capital ecosystem into account, for which cities like San Francisco and London dominate globally.

Vancouver, the bustling Canadian seaport, has been ranked the best place in the world to start a business, topping the Start-up City Index with a high quality of life, good access to office space and relative ease of getting a company off the ground.

When taking access to finance and investment into account, Berlin has traditionally been hot on the heels of London as Europe’s most robust start-up capital. In this study, the German hub came in at second place and perhaps surprisingly, it is Manchester in at third, beating competition from San Francisco and New York. In fact, Manchester far outperforms its UK rival, London, when it comes to start-up appeal, thanks to its low cost of living and the great conditions it offers for start-ups. London came in 14th place overall, but it has a way to go if it wants to compete with its northern cousin.

Rounding up the top five cities for start-ups are the Portuguese capital of Lisbon (4th) and Sweden’s Stockholm (5th) who performed well for office availability and rents and ease of starting a business.

California cities dominate the second half of the top ten, with San Diego (6th) and LA (9th) making an appearance.

And where should budding entrepreneurs avoid? At the bottom of the list is the Italian city of Rome marred by the high cost of living and low scores for ease of starting a business there. Tokyo comes in at 23rd and Paris in 24th position.

“It’s fantastic to see that despite the worries over Brexit and the continuing fallout from the GEC, Britain has managed get two cities featured in the top fifteen rankings,” Xenios Thrasyvoulou, founder and CEO of PeoplePerHour, said.

“The fact that Manchester is the third best place in the world for new startups, beating the likes of New York, Sydney and London is phenomenal, and bodes really well for the future of the so-called ‘Northern Powerhouse’. Britain has always been a leader when it comes to business and innovation. It’s really encouraging to see that despite the difficulties of recent years, that remains unchanged.”

Using a variety of data to rank each city according to the factors most likely to impact upon start-ups, such as cost, quality of life and ease of starting a new business,  PeoplePerHour created a metric to provide a definitive Index ranking the 25 cities.